Intra-urethral suppository-MUSE®

This product was released in 1997. It contains a vasodilator called Alprostadil (or Prostaglandine E1) prepared in the form of a pellet, which is inserted in to the urethra via an applicator. The medicine is expected to absorb through the urethral wall into the erectile chambers called the corpus cavernosa. It is now known that its effect is limited because it contains only one vasodilator and the drug is poorly absorbed; only a sub-therapeutic level can reach the corpus cavernosa. For these reasons, MUSE® rarely induces a complete erection. Common side- effects include urethral discomfort, bleeding, scarring and stricture. Its usefulness has been limited.

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